Biopolymer-based transdermal films of donepezil as an alternative delivery approach in Alzheimer's disease treatment.
作者： Maviye Galipoğlu , Meryem Sedef Erdal , Sevgi Güngör
DOI: 10.1208/S12249-014-0224-6
关键词: Permeation 、 Stratum corneum 、 Transdermal 、 Polyvinyl alcohol 、 Dosage form 、 Bioadhesive 、 Biopolymer 、 Chromatography 、 Chemistry 、 Donepezil
摘要: Matrix type transdermal films of donepezil (DNP) as an alternative delivery approach was designed to improve patient compliance Alzheimer disease treatment. Sodium alginate, a natural polysaccharide, used matrix-forming agent in the optimization films. Propylene glycol and dl-limonene added into plasticizer permeation enhancer, respectively. As well mechanical strength bioadhesiveness optimized DNP, impact concentration on DNP vitro across pig skin assessed. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) measurements were carried out examine effects enhancer conformational order stratum corneum intercellular lipids following study. Results showed that formulations suitable due both bioadhesive features In study indicated at 3% optimum with high drug flux. ATR-FTIR results confirmed more fluidized lipid state presence dl-limonene, indicating its enhancement effect. Regarding achieve therapeutic levels it seems be feasible deliver for management disease.
springer.com
sci-hub.se 参考文章(46)
Mohammad Rizwan, Mohammed Aqil, Abdul Ahad, Yasmin Sultana, Mushir M Ali, None, Transdermal delivery of valsartan: I. Effect of various terpenes. Drug Development and Industrial Pharmacy. ,vol. 34, pp. 618- 626 ,(2008) , 10.1080/03639040701833740
R H Guy, J Hadgraft, Transdermal Drug Delivery (2nd ed) CRC Press. ,(2003)
Sevgi Gngr, M. Sedef, Yldz zsoy, Plasticizers in Transdermal Drug Delivery Systems InTech. ,(2012) , 10.5772/38156
Paul J Sheskey, Marian E Quinn, Raymond C Rowe, Handbook of Pharmaceutical Excipients ,(1994)
Cláudia L. Silva, Jorge C. Pereira, Amílcar Ramalho, Alberto A.C.C. Pais, João J.S. Sousa, Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization Journal of Membrane Science. ,vol. 320, pp. 268- 279 ,(2008) , 10.1016/J.MEMSCI.2008.04.011
Jia-You Fang, Tsong-Long Hwang, Yann-Lii Leu, Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels International Journal of Pharmaceutics. ,vol. 250, pp. 313- 325 ,(2003) , 10.1016/S0378-5173(02)00540-9
Perry Fung Chye Lim, Xiang Yang Liu, Lifeng Kang, Paul Chi Lui Ho, Yew Weng Chan, Sui Yung Chan, Limonene GP1/PG organogel as a vehicle in transdermal delivery of haloperidol. International Journal of Pharmaceutics. ,vol. 311, pp. 157- 164 ,(2006) , 10.1016/J.IJPHARM.2005.12.042
Majella E. Lane, Skin penetration enhancers. International Journal of Pharmaceutics. ,vol. 447, pp. 12- 21 ,(2013) , 10.1016/J.IJPHARM.2013.02.040
Ben Seltzer, Donepezil: an update Expert Opinion on Pharmacotherapy. ,vol. 8, pp. 1011- 1023 ,(2007) , 10.1517/14656566.8.7.1011
Demiana I. Nesseem, S.F. Eid, S.S. El-Houseny, Development of novel transdermal self-adhesive films for tenoxicam, an anti-inflammatory drug. Life Sciences. ,vol. 89, pp. 430- 438 ,(2011) , 10.1016/J.LFS.2011.06.026