Antigenic variation of neutralization-sensitive epitopes of caprine arthritis-encephalitis lentivirus during persistent arthritis.

摘要: Caprine arthritis-encephalitis virus (CAEV), a naturally occurring lentivirus of goats, causes disease characterized by persistence and recurrent arthritis. These studies demonstrate in vitro neutralization CAEV infectivity serum from goats infected with CAEV. Serum neutralizing activity was not detectable until 10 to 36 months postinfection, titers were relatively low (less than or equal 1:8). caused antibody specific. Antigenic variants isolated cell-free joint fluid arthritic 9 18 postinfection. The delayed appearance the subsequent development antigenic may promote vivo provide stimulus for