Randomized, Multicenter Trial of Fluorouracil Plus Leucovorin Administered Either Via Hepatic Arterial or Intravenous Infusion Versus Fluorodeoxyuridine Administered Via Hepatic Arterial Infusion in Patients With Nonresectable Liver Metastases From Colorectal Carcinoma
作者： Matthias Lorenz , Hans-Helge Müller ,
DOI: 10.1200/JCO.2000.18.2.243
关键词: Colorectal cancer 、 Tolerability 、 Gastroenterology 、 Multicenter trial 、 Floxuridine 、 Hepatic arterial infusion 、 Internal medicine 、 Fluorouracil 、 Rectum 、 Medicine 、 Chemotherapy
摘要: PURPOSE: To assess the efficacy and tolerability of three treatments for patients with documented adenocarcinoma colon and/or rectum who have undergone complete resection primary tumor nonresectable liver metastases that do not exceed 75% volume. PATIENTS AND METHODS: A total 168 at 25 treatment centers were enrolled onto this prospective, multicenter, randomized study. The arms as follows: (1) fluorouracil (5-FU)/leucovorin (LV) administered via hepatic arterial infusion (HAI), (2) 5-FU/LV intravenous (IV) infusion, (3) fluorodeoxyuridine (FUDR) HAI. RESULTS: Median times to disease progression 9.2 months treated HAI 5-FU/LV, 6.6 IV 5.9 FUDR. survival FUDR 18.7 months, 17.6 12.7 respectively. There was a ne...
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