Sexual Dysfunction in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta‐Analysis

作者: Luhao Liu , Ran Kang , Shankun Zhao , Tao Zhang , Wei Zhu

DOI: 10.1111/JSM.12983

关键词: Physical therapyCohort studyMeta-analysisObstructive sleep apneaRelative riskSexual dysfunctionPublication biasInternal medicineErectile dysfunctionFemale sexual dysfunctionMedicine

摘要: Abstract Introduction Sexual dysfunction is an under-recognized problem in men and women with obstructive sleep apnea (OSA). Epidemiologic findings were inconclusive regarding the risk for sexual associated OSA. Aim The aim of this study was to examine association between OSA dysfunction. Methods PubMed, Cochrane Library, Embase databases searched observational studies on methodologic quality case–control cohort assessed Newcastle–Ottawa Scale (NOS). cross-sectional methodology checklist used study. Data pooled random-effects model. Sensitivity analyses conducted assess potential bias. Main Outcome Measure summarized using relative (RR) a 95% confidence interval (CI). Results This meta-analysis included 1,275 participants from nine studies. Five reported incidence erectile (ED); remaining four female (FSD). Pooled results demonstrated that increased ED (pooled RR = 1.82, CI: 1.12–2.97) as well FSD RR = 2.00, 1.29–3.08). Estimates total effects generally consistent sensitivity analysis. No evidence publication bias observed. Conclusions Evidence suggested individuals might have despite significant heterogeneity. More researches are warranted clarify relationship Liu L, Kang R, Zhao S, Zhang T, Zhu W, Li E, F, Wan Z. patients apnea: A systematic review meta-analysis.

参考文章(92)
Judith L. Reishtein, Greg Maislin, Terri E. Weaver, , Outcome of CPAP treatment on intimate and sexual relationships in men with obstructive sleep apnea. Journal of Clinical Sleep Medicine. ,vol. 6, pp. 221- 226 ,(2010) , 10.5664/JCSM.27817
Paola Crotti, Roberto Casale, Ciro Rampulla, Francesco Fanfulla, Silvia Malaguti, Tiziana Montagna, Silvana Salvini, Claudio Bruschi, Erectile dysfunction in men with obstructive sleep apnea: an early sign of nerve involvement. Sleep. ,vol. 23, pp. 775- 781 ,(2000) , 10.1093/SLEEP/23.6.1E
Sean M. Caples, James A. Rowley, Jeffrey R. Prinsell, John F. Pallanch, Mohamed B. Elamin, Sheri G. Katz, John D. Harwick, Surgical Modifications of the Upper Airway for Obstructive Sleep Apnea in Adults: A Systematic Review and Meta-Analysis Sleep. ,vol. 33, pp. 1396- 1407 ,(2010) , 10.1093/SLEEP/33.10.1396
Makoto Uchiyama, Masako Okawa, Kayo Shibui, Xianchen Liu, Tatsuro Hayakawa, Yuichi Kamei, Kiyohisa Takahashi, Poor compensatory function for sleep loss as a pathogenic factor in patients with delayed sleep phase syndrome. Sleep. ,vol. 23, pp. 553- 558 ,(2000) , 10.1093/SLEEP/23.4.1H
Marian Petersen, Ellids Kristensen, Søren Berg, Bengt Midgren, Long‐Term Effects of Continuous Positive Airway Pressure Treatment on Sexuality in Female Patients with Obstructive Sleep Apnea Sexual Medicine. ,vol. 1, pp. 62- 68 ,(2013) , 10.1002/SM2.18
Stephan Budweiser, Ruth Luigart, Rudolf A. Jörres, Florian Kollert, Yannick Kleemann, Wolf F. Wieland, Michael Pfeifer, Michael Arzt, Long-term changes of sexual function in men with obstructive sleep apnea after initiation of continuous positive airway pressure. The Journal of Sexual Medicine. ,vol. 10, pp. 524- 531 ,(2013) , 10.1111/J.1743-6109.2012.02968.X
Esther I Schwarz, Milo A Puhan, Christian Schlatzer, John R Stradling, Malcolm Kohler, Effect of CPAP therapy on endothelial function in obstructive sleep apnoea: A systematic review and meta‐analysis Respirology. ,vol. 20, pp. 889- 895 ,(2015) , 10.1111/RESP.12573
Nalan Köseoğlu, Hikmet Köseoğlu, Oya Itil, İbrahim Öztura, Barış Baklan, Ahmet Omer Ikiz, Ahmet Adil Esen, ORIGINAL RESEARCH—WOMEN'S SEXUAL HEALTH: Sexual Function Status in Women with Obstructive Sleep Apnea Syndrome The Journal of Sexual Medicine. ,vol. 4, pp. 1352- 1357 ,(2007) , 10.1111/J.1743-6109.2006.00302.X