Female patients with small cell lung cancer live longer than male patients

作者: Bruce E. Johnson , Seth M. Steinberg , Ruby Phelps , Margaret Edison , Stephen R. Veach

DOI: 10.1016/S0002-9343(88)80341-3

关键词: Incidence (epidemiology)Lung cancerGynecologyMale patientClinical trialFemale patientInternal medicineProportional hazards modelMedicineCancerNon small cell

摘要: Purpose The incidence of lung cancer is rising in women the United States, and recent reports have suggested that female patients treated for small cell an improved survival compared with their male counterparts. In view these findings, we decided to determine if, our patient population, live longer than men if a higher proportion are entering trials. Patients methods therapeutic clinical trials from 1973 through 1986 at National Cancer Institute-Navy Medical Oncology Branch was evaluated similarly during same time period. Results (median 13 months versus 10 months). Cox proportional hazards modeling incorporating multiple prognostic factors indicated survived significantly ( p = 0.002) when adjustment other significant made. This advantage consistent both early late periods analyzed. addition, constituted larger later period, as nationwide. Conclusion We believe it will be important comparisons current older enrolled fewer control favorable factor sex.

参考文章(17)
Steven A. Rosenberg, Vincent T. DeVita, Samuel Hellman, Cancer : Principles and Practice of Oncology ,(1982)
D. M. Geddes, P. G. Harper, J. S. Tobias, I. Bradbury, R. L. Souhami, S. G. Spiro, Prognostic Significance of Laboratory Parameters Measured at Diagnosis in Small Cell Carcinoma of the Lung Cancer Research. ,vol. 45, pp. 2878- 2882 ,(1985)
D M Finkelstein, D S Ettinger, J C Ruckdeschel, Long-term survivors in metastatic non-small-cell lung cancer: an Eastern Cooperative Oncology Group Study. Journal of Clinical Oncology. ,vol. 4, pp. 702- 709 ,(1986) , 10.1200/JCO.1986.4.5.702
J P O'Connell, M G Kris, R J Gralla, S Groshen, A Trust, J J Fiore, D P Kelsen, R T Heelan, R B Golbey, Frequency and prognostic importance of pretreatment clinical characteristics in patients with advanced non-small-cell lung cancer treated with combination chemotherapy. Journal of Clinical Oncology. ,vol. 4, pp. 1604- 1614 ,(1986) , 10.1200/JCO.1986.4.11.1604
Martin Brower, Daniel C. Ihde, Anita Johnston-Early, Paul A. Bunn, Martin H. Cohen, Desmond N. Carney, Robert W. Makuch, Mary J. Matthews, Peter A. Radice, John D. Minna, Treatment of extensive stage small cell bronchogenic carcinoma The American Journal of Medicine. ,vol. 75, pp. 993- 1000 ,(1983) , 10.1016/0002-9343(83)90880-X
John D. Minna, Robert W. Makuch, Daniel C. Ihde, Mary J. Matthews, Paul A. Bunn, Desmond N. Carney, Martin H. Cohen, Prognostic implications of stage of disease and sites of metastases in patients with small cell carcinoma of the lung treated with intensive combination chemotherapy. The American review of respiratory disease. ,vol. 123, pp. 500- 507 ,(1981) , 10.1164/ARRD.1981.123.5.500
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Peter A. Radice, Mary J. Matthews, Daniel C. Ihde, Adi F. Gazdar, Desmond N. Carney, Paul A. Bunn, Martin H. Cohen, Byron E. Fossieck, Robert W. Makuch, John D. Minna, The clinical behavior of „mixed” small cell/large cell bronchogenic carcinoma compared to „pure” small cell subtypes Cancer. ,vol. 50, pp. 2894- 2902 ,(1982) , 10.1002/1097-0142(19821215)50:12<2894::AID-CNCR2820501232>3.0.CO;2-G