T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections.

作者： Pascal Launois , Annie Drowart , Eliane Bourreau , Pierre Couppie , Claire-Michèle Farber

DOI: 10.1155/2011/640309

关键词: Immunology 、 Interferon gamma 、 Virology 、 Nontuberculous mycobacteria 、 T cell 、 Tuberculosis 、 Antigen 、 Mycobacterium tuberculosis 、 Disease 、 Medicine 、 AIDS-Related Opportunistic Infections

摘要: The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses HIV-negative tuberculosis patients. Here, we have analyzed reactivity against PPD Ag85 HIV-infected individuals, without or clinical symptoms of tuberculosis, AIDS patients disease caused by nontuberculous mycobacteria. Whereas to were not significantly different HIV-positive volunteers, decreased the (CDC-A CDC-B) group. Tuberculosis demonstrated low Ag85, irrespective HIV infection, finally suffering NTM infections completely nonreactive Ag85. A one-year follow-up twelve individuals indicated developing highlighting protective potential this antigen.

参考文章(38)

Elizabeth L Corbett, HIV and tuberculosis: surveillance revisited. International Journal of Tuberculosis and Lung Disease. ,vol. 7, pp. 709- ,(2003)

James C. Sacchettini, Donald R. Ronning, Thomas Klabunde, Gurdyal S. Besra, Varalakshmi D. Vissa, John T. Belisle, Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines Nature Structural & Molecular Biology. ,vol. 7, pp. 141- 146 ,(2000) , 10.1038/72413

P G Pal, M A Horwitz, Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis. Infection and Immunity. ,vol. 60, pp. 4781- 4792 ,(1992) , 10.1128/IAI.60.11.4781-4792.1992

P Launois, R DeLeys, M N Niang, A Drowart, M Andrien, P Dierckx, J L Cartel, J L Sarthou, J P Van Vooren, K Huygen, T-cell-epitope mapping of the major secreted mycobacterial antigen Ag85A in tuberculosis and leprosy Infection and Immunity. ,vol. 62, pp. 3679- 3687 ,(1994) , 10.1128/IAI.62.9.3679-3687.1994

H. SILVEIRA, D. ORDWAY, H. DOCKRELL, M. JACKSON, F. VENTURA, Cell-mediated immune responses to mycobacterial antigens in patients with pulmonary tuberculosis and HIV infection Clinical and Experimental Immunology. ,vol. 110, pp. 26- 34 ,(1997) , 10.1111/J.1365-2249.1997.509-CE1407.X

Ann LN Chapman, Mwansa Munkanta, Katalin A Wilkinson, Ansar A Pathan, Katie Ewer, Helen Ayles, William H Reece, Alwyn Mwinga, Peter Godfrey-Faussett, Ajit Lalvani, None, Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells. AIDS. ,vol. 16, pp. 2285- 2293 ,(2002) , 10.1097/00002030-200211220-00008

B. Autran, G. Carcelain, T. S. Li, C. Blanc, D. Mathez, R. Tubiana, C. Katlama, P. Debré, J. Leibowitch, Positive Effects of Combined Antiretroviral Therapy on CD4+ T Cell Homeostasis and Function in Advanced HIV Disease Science. ,vol. 277, pp. 112- 116 ,(1997) , 10.1126/SCIENCE.277.5322.112

Jaap T. van Dissel, Sandra M. Arend, Corine Prins, Peter Bang, Pernille Nyholm Tingskov, Karen Lingnau, Jan Nouta, Michèl R. Klein, Ida Rosenkrands, Tom H.M. Ottenhoff, Ingrid Kromann, T. Mark Doherty, Peter Andersen, Ag85B–ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers Vaccine. ,vol. 28, pp. 3571- 3581 ,(2010) , 10.1016/J.VACCINE.2010.02.094

Stefan H. E. Kaufmann, Envisioning future strategies for vaccination against tuberculosis Nature Reviews Immunology. ,vol. 6, pp. 699- 704 ,(2006) , 10.1038/NRI1920

10.

Ian M. Orme, Preclinical testing of new vaccines for tuberculosis: a comprehensive review. Vaccine. ,vol. 24, pp. 2- 19 ,(2006) , 10.1016/J.VACCINE.2005.07.078

T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections.

来源期刊

我的账户

T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections.

来源期刊

相似文章 10

我的账户