New Frontiers in Selective Human MAO-B Inhibitors

摘要: Accumulating evidence shows a relationship between the human MAO-B (hMAO-B) enzyme and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline disorders, aggressiveness violence in crime, obsessive-compulsive depression, suicide, schizophrenia, anorexia nervosa, migraine, dementia, PD. Thus, represents an attractive target for treatment of number diseases. The discovery, development, therapeutic use drugs that inhibit are major challenges future therapy. Various compounds selectively this isoform have been discovered recently. These agents synthetic or natural products their analogues, including chalcones, pyrazoles, chromones, coumarins, xanthines, isatin derivatives, thiazolidindiones, (thiazol-2-yl)hydrazones, analogues marketed drugs. Despite considerable efforts understanding binding interaction with specific substrates inhibitors, structural ...