Pentoxifylline Reduces Skeletal Muscle Necrosis after Acute Hindlimb Ischemia in Rats

摘要: Complete ischemia in the left hindlimb was maintained for 3.5 h 16 rats randomized into two equal groups. One group served as control, other treated with pentoxifylline before, during and after ischemic period. The animals were killed 72 later, anterior tibial muscles prepared histological investigation. most severely damaged had a central core complete necrosis of all muscle fibers, disintegrated capillaries no macrophage infiltration. This zone, which called area resorption, surrounded by an incomplete partly resorbed intact marked completely only narrow subfascial zone. total areas resorption measured percent cross-sectional each muscle. There extensive both infarcted 93% control 89% (NS). corresponding 23 6% (p = 0.01). study indicates that has some protective effect on damage. However, this is marginal compared to moderate hypothermic treatment.