Effects of pentoxifylline on the cytokines that may play a role in rejection and resistive index in renal transplant recipients.

摘要: Pentoxifylline (PTX) is a nonselective phosphodiesterase inhibitor that inhibits the production of TNFα and IL6 IL-10 cytokines. In renal rejection TNFα, IL-6, may have important roles. this study, 22 transplant recipients treated with tacrolimus, prednisolone, mycophenolate mofetil were prescribed PTX (2 × 600 mg/d) for 3 months (GI), 20 similar patients not receiving used as controls (GII). Stable subjects whose serum creatinine was lower than 1.8 mg/dL more 6 posttransplant, enrolled into study if blood pressure well controlled there no diabetes mellitus, infection, or inflammation. At end TNF-α decreased from 4.2 ± 2.1 to 2.4 0.7 (P = .001) 4.0 2.2 3.9 1.7 .718), also 3.90 1.9 2.38 0.6 4.02 1.6 3.82 1.5 .225) in GI GII, respectively. For alterations between baseline last visit GII significant < .002 all). Resistive index (RI) but difference marginal. In summary levels stable PTx. RI marginally secondary PTx treatment. tolerated free side effects. did affect tacrolimus other biochemical hematological parameters.