Pentoxifylline inhibits transforming growth factor-beta signaling and renal fibrosis in experimental crescentic glomerulonephritis in rats.

作者: Yee-Yung Ng , Yung-Ming Chen , Tun-Jun Tsai , Xiao-Ru Lan , Wu-Chang Yang

DOI: 10.1159/000150600

关键词:

摘要: Background/Aims: Pentoxifylline (PTX) has been shown to inhibit renal inflammation in a rat model of crescentic glomerulonephritis. The present study investigated the role PTX

参考文章(28)
SHUEI-LIONG LIN, YUNG-MING CHEN, WEN-CHIH CHIANG, TUN-JUN TSAI, WAN-YU CHEN, Pentoxifylline: a potential therapy for chronic kidney disease. Nephrology. ,vol. 9, pp. 198- 204 ,(2004) , 10.1111/J.1440-1797.2004.00267.X
WANSHENG WANG, VIJAY KOKA, HUI Y LAN, Transforming growth factor-beta and Smad signalling in kidney diseases. Nephrology. ,vol. 10, pp. 48- 56 ,(2005) , 10.1111/J.1440-1797.2005.00334.X
Yung-Ming Chen, Chiang-Ting Chien, Mi-I Hu-Tsai, Kwan-Dun Wu, Chien-Chen Tsai, Ming-Shiou Wu, Tun-Jun Tsai, Pentoxifylline attenuates experimental mesangial proliferative glomerulonephritis Kidney International. ,vol. 56, pp. 932- 943 ,(1999) , 10.1046/J.1523-1755.1999.00636.X
Luca Aresu, Maria Pia Rastaldi, Eugenio Scanziani, James Baily, Enrico Radaelli, Paola Pregel, Federico Valenza, Epithelial–mesenchymal transition (EMT) of renal tubular cells in canine glomerulonephritis Virchows Archiv. ,vol. 451, pp. 937- 942 ,(2007) , 10.1007/S00428-007-0482-8
Eric G. Neilson, Raghu Kalluri, Epithelial-mesenchymal transition and its implications for fibrosis. Journal of Clinical Investigation. ,vol. 112, pp. 1776- 1784 ,(2003) , 10.1172/JCI20530
Didier Ducloux, Catherine Bresson-Vautrin, Jean-Marc Chalopin, Use of pentoxifylline in membranous nephropathy. The Lancet. ,vol. 357, pp. 1672- 1673 ,(2001) , 10.1016/S0140-6736(00)04830-3
Yoshiharu Nishitani, Masayuki Iwano, Yukinari Yamaguchi, Koji Harada, Kimihiko Nakatani, Yasuhiro Akai, Toshihiko Nishino, Hideo Shiiki, Masao Kanauchi, Yoshihiko Saito, Eric G. Neilson, Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN. Kidney International. ,vol. 68, pp. 1078- 1085 ,(2005) , 10.1111/J.1523-1755.2005.00500.X
Jun-Ming Fan, Xiao-Ru Huang, Yee-Yung Ng, David J. Nikolic-Paterson, Wei Mu, Robert C. Atkins, Hui Y. Lan, Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-β1-dependent mechanism in vitro American Journal of Kidney Diseases. ,vol. 37, pp. 820- 831 ,(2001) , 10.1016/S0272-6386(01)80132-3
Shuei-Liong Lin, Yung-Ming Chen, Chiang-Ting Chien, Wen-Chih Chiang, Chien-Chen Tsai, Tun-Jun Tsai, Pentoxifylline attenuated the renal disease progression in rats with remnant kidney. Journal of The American Society of Nephrology. ,vol. 13, pp. 2916- 2929 ,(2002) , 10.1097/01.ASN.0000034909.10994.8A
Kiichiro Jinde, David J. Nikolic-Paterson, Xiao R. Huang, Hideto Sakai, Kiyoshi Kurokawa, Robert C. Atkins, Hui Y. Lan, Tubular phenotypic change in progressive tubulointerstitial fibrosis in human glomerulonephritis American Journal of Kidney Diseases. ,vol. 38, pp. 761- 769 ,(2001) , 10.1053/AJKD.2001.27693