Application of Proteomics and Peptidomics to COPD

摘要: Chronic obstructive pulmonary disease (COPD) is a complex disorder involving both airways and lung parenchyma, usually associated with progressive poorly reversible airflow limitation. In order to better characterize the phenotypic heterogeneity prognosis of patients COPD, there currently an urgent need for discovery validation reliable biomarkers. Within this context, proteomic peptidomic techniques are emerging as very valuable tools that can be applied systemic samples, including peripheral blood, induced sputum, exhaled breath condensate, bronchoalveolar lavage fluid, tissues. Identification COPD biomarkers by means approaches thus also lead new molecular targets potentially useful improve personalize therapeutic management widespread respiratory disease.