Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease

摘要: Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast progression mortality. Thus, there urgent need clarify molecular mechanisms responsible for this condition order identify new biomarkers therapeutic targets. Processes including oxidant/antioxidant, protease/antiprotease, proliferative/antiproliferative balance control of response become dysfunctional during aging as well COPD. Recently it was suggested Sirtuin 1 (SIRT1), antiaging molecule involved oxidative stress chronic inflammation, implicated both development The present review focuses on involvement SIRT1 regulation redox state, premature senescence, all crucial characteristics COPD phenotypes. Recent evidence corroborating statement “aging theory COPD” also discussed.