Receptor regulation of phosphoinositidase C

摘要: Numerous hormones, neurotransmitters and growth factors regulate intracellular events by acting at cell surface receptors which are coupled to the generation of inositol phospholipid-derived messengers. Receptors trigger hydrolysis phospholipids activating phosphoinositidase C (PIC) enzymes. At least four families genes encode structurally distinct PIC enzymes it is likely that isoenzymes participate in different pathways signal transduction. Two modes receptor regulation have been identified these involve isoenzymes. In first these, PIC-gamma a substrate for factor protein-tyrosine kinases. The second involves PIC-beta plus other whose activities regulated G proteins response agonist binding protein-linked receptors. two types activity each may control