The molecular genetics of colorectal neoplasia

作者: Stanley R. Hamilton

DOI: 10.1016/0016-5085(93)90003-U

关键词: ImmunologyMolecular geneticsColorectal cancerColonic diseaseBiologyRectal diseaseGeneral surgery

摘要: The Commemorative Essays for the 50th year of GASTROENTEROLOGY provide a historical perspective on advances and accomplishments in understanding gastrointestinal diseases. history molecular genetics colorectal neoplasia undoubtedly occupies smallest portion last half century that cover, because entire body knowledge has accumulated less than decade. Nonetheless, clinical application this to impact incidence mortality from cancer is now at hand.

参考文章(3)
D Sidransky, T Tokino, Hamilton, K. Kinzler, B Levin, P Frost, B Vogelstein, Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science. ,vol. 256, pp. 102- 105 ,(1992) , 10.1126/SCIENCE.1566048
Eric R. Fearon, Bert Vogelstein, A genetic model for colorectal tumorigenesis Cell. ,vol. 61, pp. 759- 767 ,(1990) , 10.1016/0092-8674(90)90186-I
Bert Vogelstein, Eric R Fearon, Stanley R Hamilton, Scott E Kern, Ann C Preisinger, Mark Leppert, Yusuke Nakamura, Ray White, Alida MM Smits, Johannes L Bos, Genetic alterations during colorectal-tumor development. The New England Journal of Medicine. ,vol. 319, pp. 525- 532 ,(1988) , 10.1056/NEJM198809013190901