Oncogenes and tumor suppressor genes.
作者： M. Ponz de Leon
DOI: 10.1007/978-3-642-85076-9_4
关键词: DNA 、 Suppressor 、 Biology 、 Lesion 、 Gene 、 Cancer research 、 Familial adenomatous polyposis 、 Adenomatous polyposis coli 、 Tumor suppressor gene 、 Carcinogenesis
摘要: During the last 20–30 years, a large body of epidemiologic, cytogenetic, and experimental studies have supported hypothesis that tumors are caused by genetic damage. The recent advances in molecular biology definitively proved this was correct, at present there is no doubt basic lesion malignant cell an abnormality DNA structure or sequence which results uncontrolled growth. Two particular classes genes been identified — oncogenes tumor suppressor major importance initiation progression human malignancies [1].
springer.com
narcis.nl参考文章(60)
Alfred G. Knudson, Genetics and Etiology of Human Cancer Advances in human genetics. ,vol. 8, pp. 1- 66 ,(1977) , 10.1007/978-1-4615-8267-0_1
T Mitsudomi, Seth M Steinberg, Marion M Nau, David Carbone, Domenico D'Amico, Sara Bodner, Herbert K Oie, R Ilona Linnoila, James L Mulshine, John D Minna, None, p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene. ,vol. 7, pp. 171- 180 ,(1992)
Maurizio Ponz de Leon, L Roncucci, Paola Di Donato, Loris Tassi, Ombretta Smerieri, Maria Grazia Amorico, Gianni Malagoli, Dario De Maria, Aldo Antonioli, Nabil J Chahin, Mario Perini, Gianpiero Rigo, Giuseppe Barberini, Antonio Manenti, Guido Biasco, Luigi Barbara, Pattern of Epithelial Cell Proliferation in Colorectal Mucosa of Normal Subjects and of Patients with Adenomatous Polyps or Cancer of the Large Bowel Cancer Research. ,vol. 48, pp. 4121- 4126 ,(1988)
Sipra Banerjee, Lagnajita Ghosh, Huan-Chao Chen, Umesh Patel, Liming Wang, Mutation in the nm23 Gene Is Associated with Metastasis in Colorectal Cancer Cancer Research. ,vol. 53, pp. 717- 720 ,(1993)
P. W. Hinds, S. J. Baker, C. A. Finlay, A. J. Levine, R. S. Quartin, B. Vogelstein, E. R. Fearon, Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes Cell Growth & Differentiation. ,vol. 1, pp. 571- 580 ,(1990)
A Condie, J Prosser, U Chetty, H J Evans, C Coles, C M Steel, p53 mutations in breast cancer. Cancer Research. ,vol. 52, pp. 5291- 5298 ,(1992)
Daniel J. Schaid, Stephen N. Thibodeau, John A. Lust, Gary D. Bren, Herschel A. Carpenter, John S. Kovach, Julie Cunningham, Elizabeth Rizza, Expression of p53 and 17p allelic loss in colorectal carcinoma. Cancer Research. ,vol. 52, pp. 1974- 1980 ,(1992)
Robert A. Weinberg, Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis. Cancer Research. ,vol. 49, pp. 3713- 3721 ,(1989)
Francesco Pezzella, Helen Turley, Isinzu Kuzu, Mohammed Fahim Tungekar, Michael S. Dunnill, Chris B. Pierce, Adrian Harris, Kevin C. Gatter, David Y. Mason, bcl-2 Protein in Non-Small-Cell Lung Carcinoma The New England Journal of Medicine. ,vol. 329, pp. 690- 694 ,(1993) , 10.1056/NEJM199309023291003
E. E. Deschner, Cell proliferation and colonic neoplasia. Scandinavian Journal of Gastroenterology. ,vol. 151, pp. 94- 97 ,(1988) , 10.3109/00365528809095919