p53 mutations in breast cancer.

摘要: We have identified and analyzed 41 mutations in p53 sporadic breast tumors from 136 unselected cancer patients estimate that approximately 40% of such contain mutations. The frequency G-T transversions the incidence guanosine nontranscribed strand gene were found to be higher than expected, we suggest, therefore, exogenous carcinogens an etiological role cancers. Mutations recorded 44 codons gene, with no obvious mutational hot-spots, although at 175, 194, 273, 280 accounted for 25% changes. One germ-line mutation was so conclude constitutional may uncommon factor cancer.