Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development

摘要: Abstract CDP/Cux/Cut proteins are an evolutionarily conserved family of containing several DNA binding domains: one Cut homeodomain and one, two or three repeats. In Drosophila melanogaster, genetic studies indicated that functions as a determinant cell-type specification in tissues, notably the peripheral nervous system, wing margin Malpighian tubule. Moreover, was found to be target effector Notch signaling pathway. vertebrates, same appear fulfilled by cut-related genes with distinct patterns expression. Cloning cDNA for CCAAT-displacement protein (CDP) revealed it human homologue Cut. CDP later previously characterized histone nuclear factor D (HiNF-D). its mouse counterpart, Cux, were also reported interact regulatory elements from large number genes, including matrix attachment regions (MARs). CDP/Cut generally function transcriptional repressors, although participation activation is suggested some data. Repression involves competition site occupancy active repression via recruitment deacetylase activity. Various combinations repeats homeodomains can generate activities. These activities elevated proliferating cells decrease during terminal differentiation. One activity, involving homeodomain, upregulated S phase. regulated post-translational modification events phosphorylation, dephosphorylation, acetylation. The CUTL1 gene mapped 7q22, chromosomal region frequently rearranged various cancers.