Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development
作者： Ann M. Ranger , Mohamed Oukka , Jyothi Rengarajan , Laurie H. Glimcher
DOI: 10.1016/S1074-7613(00)80660-3
关键词: Fas ligand 、 NFAT 、 Regulator 、 Immunology 、 Phenotype 、 Cell biology 、 Apoptosis 、 Biology 、 Immunoglobulin E 、 Mutant 、 Homeostasis
摘要: Abstract Nuclear factor of activated T cells (NFAT) is a critical regulator early gene transcription in response to TCR-mediated signals. Here, we show that mice lacking both NFATp and NFAT4 develop profound lymphoproliferative disorder likely due lowered threshold for TCR signaling coupled with increased resistance apoptosis secondary defective FasL expression. NFAT mutant also have allergic blepharitis, interstitial pneumonitis, 10 3 4 fold increase serum IgG1 IgE levels, dramatic selective Th2 cytokines. This phenotype may be ascribed unopposed occupancy the IL-4 promoter by NFATc. Our data demonstrate lymphoid homeostasis activation require balance among family members.
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