Hippocampal sclerosis and TDP‐43 pathology in aging and Alzheimer disease

摘要: Hippocampal sclerosis (HS) refers to the pathology of severe neuronal loss and astrogliosis CA1 and/or subiculum. HS was first noted on macroscopic examination brain 8 epilepsy cases in 18251, but has been increasingly recognized dementia where it is often linked with neurodegenerative diseases particularly Alzheimer’s disease (AD), 2-4 frontotemporal lobar degeneration (FTLD)3,5 as well vascular diseases.3,4,6-8 Occasionally, detected absence apparent degenerative or disease,2,4,9,10 which case variably called pure 11 dementia.12 also aging oldest old, without AD, these have described aging.13-15 Most data regards are obtained from clinic studies suggest that associated dementia.4,9,16 There little about independent contribution likelihood a diagnosis mild cognitive impairment (MCI) clinical AD community dwelling subjects. Moreover, profile those compared other ill-defined, limited neuropsychological testing do not provide information extent involvement specific domains.14,17 Recently, TAR-DNA binding protein 43 kDa (TDP-43) reported 89%-90% cases;14,18 however there severity, distribution role TDP-43 HS. In this study, hypothesis related dementia, probable MCI, impaired episodic memory tested 636 autopsied subjects (358 <90 278 ≥ 90 years) Religious Order Study (ROS) Rush Memory Aging Project (MAP). The relation between age-related pathologies were investigated.