Mixed pathology is more likely in black than white decedents with Alzheimer dementia.

摘要: Objective: To compare the burden of neuropathology in black and white participants with clinical Alzheimer disease (AD). Methods: Participants included 122 persons enrolled Rush Alzheimer9s Disease Clinical Core, a prospective cohort study AD. Forty-one decedents were matched two-to-one to 81 according age at death, sex, years education, cognition proximate death. We examined common brain pathologies related dementia (AD, Lewy body, macroscopic microinfarct pathology) arteriolar sclerosis atherosclerosis. calculated frequency each pathology both alone combination (mixed pathologies). Racial differences odds single vs mixed pathologies, vessel its severity, using logistic regression analyses. Results: AD was confirmed >93% dementia. However, less likely have as than (19.5% 42.0%), more an additional (70.7% 50.6%), particularly bodies, pathology, infarcts. Black also had severe Conclusion: are compared age-, sex-, education-, cognition-matched