A race effect on amyloid deposition
作者： Gaël Chételat , Murray Grossman
DOI: 10.1212/WNL.0000000000002924
关键词: Amyloidosis 、 Internal medicine 、 Clinical trial 、 Cognition 、 Alzheimer's disease 、 Disease 、 Amyloid 、 Pathophysiology 、 Dementia 、 Medicine 、 Oncology
摘要: The development of PET radiotracers, allowing visualization amyloid in the brains living patients, has been a major breakthrough field Alzheimer disease (AD). For example, presence brain at preclinical/predementia stage may not be sufficient for developing AD, but is associated with increased risk progression to AD dementia.1 identification determinants amyloidogenesis and factors that influence prevalence positivity crucial several reasons: (1) help understand physiopathology more specifically cause β-amyloid accumulation (which would turn develop disease-modifying treatments); (2) define target populations clinical trials testing antiamyloid drugs trial endpoints; (3) act on these (e.g., modifiable lifestyle factors) decrease positivity. main known without dementia are age (with from 50 70 years increasing 10% 44% cognitively normal individuals 27% 71% patients mild cognitive impairment [MCI]) APOE e4 2–3 times higher carriers than noncarriers).2 Education/cognitive activity often thought modulate burden interaction age, while sex deposition less clear.3
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