Ex vivo MRI transverse relaxation in community based older persons with and without Alzheimer's dementia.

摘要: Abstract Alterations of the transverse relaxation rate, R 2 , measured using MRI, are observed in older persons with Alzheimer’s (AD) dementia. However, spatial pattern these alterations and degree to which they reflect accumulation common age-related neuropathologies unknown. In this study, we characterized profile post-mortem brains clinical diagnosis AD dementia investigated how differs after accounting for neuropathologic indices AD, cerebral infarcts, Lewy body disease, hippocampal sclerosis transactive response DNA-binding protein 43. Data came from 567 donated by participants two cohort studies aging was quantified fast spin echo imaging. Voxelwise linear regression examined between subjects diagnosed at death those no cognitive impairment. Voxels showing significant were clustered into regions interest (ROIs). Three profiles compared, adjusted (1) demographics only; (2) pathology; (3) demographics, pathology other neuropathologies. throughout hemisphere, most commonly white matter. Of distinct ROIs identified, largest region encompassed large portions matter all lobes. This ROI became smaller size but remained largely intact adjusting indices. Further, identify improved accuracy, above beyond (p  not solely reflective neuropathologies, suggesting that mechanisms work.