Associations of Brain Structure With Adiposity and Changes in Adiposity in a Middle-Aged and Older Biracial Population

摘要: Background Studies of adiposity and brain pathology in African Americans (AA) are sparse despite higher rates obesity, dementia, dementia-associated AA. This study examined relations to white matter hyperintensities (WMH) total volume (TBV) AA non-Hispanic whites (NHW). Methods Waist circumference (WC) body mass index (BMI) were measured the Genetic Epidemiology Network Arteriopathy at Visits 1 (mean age 57 [±11]) 2 61 [±10], mean 5.2 years later). Brain MRIs obtained shortly after Visit 1,702 participants (64% women, 48% AA). Multilevel linear regression using generalized estimating equation estimated associations (cross-sectional) or changes with WMH (accounting for intracranial size) TBV adjusting demographics, cardiovascular risk factors, incorporating adiposity-by-race interactions. Adiposity-by-age interactions examined. Results Concurrent was inversely associated BMI (β = -2.76 [95% confidence interval (CI): -4.99, -0.53]) WC -2.19 [CI: -4.04, -0.34]). negatively -0.04 -0.06, -0.01]) and, among NHW, -0.02]) but not WC. increases lower -16.20, -30.34, -2.06]) NHW -14.02, 8.51]), although race-by-adiposity supported. MRI outcomes. Conclusion Greater measures obesity which common mid-life, could be detrimental health, particularly