Expanding the linear dynamic range for multiple reaction monitoring in quantitative liquid chromatography-tandem mass spectrometry utilizing natural isotopologue transitions.
作者： Hanghui Liu , Lily Lam , Purnendu K. Dasgupta
DOI: 10.1016/J.TALANTA.2011.09.063
关键词: Ion 、 Dynamic range 、 Analytical chemistry 、 Selected reaction monitoring 、 Tandem mass spectrometry 、 Liquid chromatography–mass spectrometry 、 Saturation (chemistry) 、 Chemistry 、 Isotopologue 、 Order of magnitude 、 Chromatography
摘要: Abstract We describe a method for expanding the linear dynamic range multiple reaction monitoring (MRM) in quantitative liquid chromatography/tandem mass spectrometry (LC–MS/MS) using additional transitions isotopologues. In addition to regular transition highest possible sensitivity, corresponding less abundant isotopologue ions was utilized. This decreases saturation at ion detector; sensitivity reduction increases upper limit. demonstrated this rat plasma assay candidate flavor compound; increased by an order of magnitude from 3 6000 ng/mL with MRM alone 3–60,000 ng/mL additionally transition.
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