Initiation of NALT Organogenesis Is Independent of the IL-7R, LTβR, and NIK Signaling Pathways but Requires the Id2 Gene and CD3−CD4+CD45+ Cells
作者： Satoshi Fukuyama , Takachika Hiroi , Yoshifumi Yokota , Paul D. Rennert , Manabu Yanagita
DOI: 10.1016/S1074-7613(02)00339-4
关键词: Signal transduction 、 Organogenesis 、 Cell biology 、 Cytokine 、 Gene 、 Biology 、 Peripheral lymph 、 Adoptive cell transfer 、 CD3 、 Immunology 、 Lymphatic system
摘要: Abstract Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent the programmed cytokine cascade necessary for formation Peyer's patches (PP) and peripheral lymph nodes (PLN), a which consists IL-7R, LTα1β2/LTβR, NIK. However, subsequent organization NALT seems to be controlled by these signaling cascades since maturation structure generally incomplete in those cascade-deficient mice. as well PP PLN are completely absent Id2 −/− organogenesis initiated following adoptive transfer CD3 − CD4 + CD45 cells into mice, constituting direct evidence that inducer can provide an IL-7R-, LTα1β2/LTβR-, NIK-independent pathway secondary development.
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