Subharmonic emission as an indicator of ultrasonically-induced biological damage

摘要: Abstract This paper describes work in which subharmonic emissions from ultrasonically irradiated biological samples are integrated over time, and the resultant signal (which is believed to be indicative of cavitation activity) found correlate well with extent cellular damage. Specificially, three studies have been carried out, energy emitted suspension cultures V79 cells during exposure 1 MHz ultrasound. The effect raised ambient pressure sample rotation speed on occurrence cavitation, related cell death, investigated. Use emission technique has also yielded additional evidence for an induced mechanism damage that neither thermal nor cavitational origin, experiments where exposed ultrasound whilst being held at elevated temperature(43°C). potential use monitoring as a quantitative predictor damage, both vitro vivo , discussed.