Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms.
作者： Yu Dong , Lorenz Poellinger , Jan-Åke Gustafsson , Sam Okret
关键词: Endocrinology 、 Steroid hormone 、 Cell culture 、 Biology 、 Glucocorticoid 、 Gene expression 、 Protein turnover 、 Internal medicine 、 Molecular biology 、 Glucocorticoid receptor 、 Messenger RNA 、 Transcriptional regulation
摘要: The mechanism of ligand-induced (homologous) down-regulation of the glucocorticoid receptor (GR) has been studied. Dexamethasone caused a down-regulation of the levels of …
oup.com
endojournals.org参考文章(53)
D S Ucker, K R Yamamoto, Early events in the stimulation of mammary tumor virus RNA synthesis by glucocorticoids. Novel assays of transcription rates. Journal of Biological Chemistry. ,vol. 259, pp. 7416- 7420 ,(1984) , 10.1016/S0021-9258(17)42806-7
F. Svec, M. Rudis, Glucocorticoids regulate the glucocorticoid receptor in the AtT-20 cell. Journal of Biological Chemistry. ,vol. 256, pp. 5984- 5987 ,(1981) , 10.1016/S0021-9258(19)69116-7
Kazue Tsukanaka, Fumihide Isohashi, Hisao Fukushima, Yukiya Sakamoto, Masako Terada, Yoko Nakanishi, Alteration in Binding of Dexamethasone to Glucocorticoid Receptors in Regenerating Rat Liver after Partial Hepatectomy Cancer Research. ,vol. 39, pp. 5132- 5135 ,(1979)
O Wrange, S Okret, M Radojćić, J Carlstedt-Duke, J A Gustafsson, Characterization of the purified activated glucocorticoid receptor from rat liver cytosol. Journal of Biological Chemistry. ,vol. 259, pp. 4534- 4541 ,(1984) , 10.1016/S0021-9258(17)43079-1
G R Crabtree, A Munck, K A Smith, Glucocorticoids and lymphocytes. II. Cell cycle-dependent changes in glucocorticoid receptor content. Journal of Immunology. ,vol. 125, pp. 13- 17 ,(1980)
Don J. Diamond, Howard M. Goodman, Regulation of growth hormone messenger RNA synthesis by dexamethasone and triiodothyronine: Transcriptional rate and mRNA stability changes in pituitary tumor cells Journal of Molecular Biology. ,vol. 181, pp. 41- 62 ,(1985) , 10.1016/0022-2836(85)90323-7
D. Owen, L. C. Kühn, Noncoding 3' sequences of the transferrin receptor gene are required for mRNA regulation by iron The EMBO Journal. ,vol. 6, pp. 1287- 1293 ,(1987) , 10.1002/J.1460-2075.1987.TB02366.X
J E Kalinyak, R I Dorin, A R Hoffman, A J Perlman, Tissue-specific regulation of glucocorticoid receptor mRNA by dexamethasone. Journal of Biological Chemistry. ,vol. 262, pp. 10441- 10444 ,(1987) , 10.1016/S0021-9258(18)60980-9
W R McIntyre, H H Samuels, Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form. Journal of Biological Chemistry. ,vol. 260, pp. 418- 427 ,(1985) , 10.1016/S0021-9258(18)89748-4
S Rosewicz, A R McDonald, B A Maddux, I D Goldfine, R L Miesfeld, C D Logsdon, Mechanism of glucocorticoid receptor down-regulation by glucocorticoids. Journal of Biological Chemistry. ,vol. 263, pp. 2581- 2584 ,(1988) , 10.1016/S0021-9258(18)69104-5