Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA.
作者： Guangfu Jin , Siqun Lilly Zheng , Hans Lilja , Seong-Tae Kim , Sha Tao
DOI: 10.1593/NEO.121620
关键词: Prostate-specific antigen 、 Genotyping 、 Genome-wide association study 、 Prostate cancer 、 Biology 、 Single-nucleotide polymorphism 、 Population 、 Case-control study 、 Internal medicine 、 Bioinformatics 、 Oncology 、 Genotype
摘要: Abstract BACKGROUND: Percentage of free-to-total prostate-specific antigen (%fPSA) is an independent predictor risk for prostate cancer among men with modestly elevated level total PSA (tPSA) in blood. Physiological and pathological factors have been shown to influence the %fPSA value diagnostic accuracy. MATERIALS/METHODS: To evaluate genetic determinants %fPSA, we conducted a genome-wide association study serum by genotyping 642,584 single nucleotide polymorphisms (SNPs) 3192 European ancestry, each tPSA 2.5 10 ng/ml, that were recruited REduction DUtasteride Prostate Cancer Events study. Single P −5 further evaluated controls population-based case-control Sweden (2899 cases 1722 male controls), including 464 having levels ng/ml. RESULTS: We identified two loci associated at significance ( −8 ). The first SNP was rs3213764 = 6.45 × −10 ), nonsynonymous variant (K530R) ATF7IP gene 12p13. This also nominally .015). second locus
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sci-hub.se 参考文章(30)
Stephen D. Mikolajczyk, Mohammad S. Saedi, Lisa S. Millar, Amita S. Goel, Abhay Kumar, Expression of Pro Form of Prostate-specific Antigen by Mammalian Cells and Its Conversion to Mature, Active Form by Human Kallikrein 2 Cancer Research. ,vol. 57, pp. 3111- 3114 ,(1997)
H Lilja, A Christensson, U Dahlén, M T Matikainen, O Nilsson, K Pettersson, T Lövgren, Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin. Clinical Chemistry. ,vol. 37, pp. 1618- 1625 ,(1991) , 10.1093/CLINCHEM/37.9.1618
S. Lilly Zheng, Jielin Sun, Fredrik Wiklund, Shelly Smith, Pär Stattin, Ge Li, Hans-Olov Adami, Fang-Chi Hsu, Yi Zhu, Katarina Bälter, A. Karim Kader, Aubrey R. Turner, Wennuan Liu, Eugene R. Bleecker, Deborah A. Meyers, David Duggan, John D. Carpten, Bao-Li Chang, William B. Isaacs, Jianfeng Xu, Henrik Grönberg, Cumulative Association of Five Genetic Variants with Prostate Cancer The New England Journal of Medicine. ,vol. 358, pp. 910- 919 ,(2008) , 10.1056/NEJMOA075819
Rosalind A Eeles, , Zsofia Kote-Jarai, Graham G Giles, Ali Amin Al Olama, Michelle Guy, Sarah K Jugurnauth, Shani Mulholland, Daniel A Leongamornlert, Stephen M Edwards, Jonathan Morrison, Helen I Field, Melissa C Southey, Gianluca Severi, Jenny L Donovan, Freddie C Hamdy, David P Dearnaley, Kenneth R Muir, Charmaine Smith, Melisa Bagnato, Audrey T Ardern-Jones, Amanda L Hall, Lynne T O'Brien, Beatrice N Gehr-Swain, Rosemary A Wilkinson, Angie Cox, Sarah Lewis, Paul M Brown, Sameer G Jhavar, Malgorzata Tymrakiewicz, Artitaya Lophatananon, Sarah L Bryant, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Cyril Fisher, Charles Jamieson, Colin S Cooper, Dallas R English, John L Hopper, David E Neal, Douglas F Easton, , , Multiple newly identified loci associated with prostate cancer susceptibility. Nature Genetics. ,vol. 40, pp. 316- 321 ,(2008) , 10.1038/NG.90
Ian M Thompson, Donna Pauler Ankerst, Chen Chi, M Scott Lucia, Phyllis J Goodman, John J Crowley, Howard L Parnes, Charles A Coltman, Operating Characteristics of Prostate-Specific Antigen in Men With an Initial PSA Level of 3.0 ng/mL or Lower JAMA. ,vol. 294, pp. 66- 70 ,(2005) , 10.1001/JAMA.294.1.66
A. J. Vickers, A. M. Cronin, T. Bjork, J. Manjer, P. M. Nilsson, A. Dahlin, A. Bjartell, P. T. Scardino, D. Ulmert, H. Lilja, Prostate specific antigen concentration at age 60 and death or metastasis from prostate cancer: case-control study BMJ. ,vol. 341, pp. 594- ,(2010) , 10.1136/BMJ.C4521
Anders CHRISTENSSON, Carl-Bertil LAURELL, Hans LILJA, Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors. FEBS Journal. ,vol. 194, pp. 755- 763 ,(1990) , 10.1111/J.1432-1033.1990.TB19466.X
Andrew W. Roddam, Michael J. Duffy, Freddie C. Hamdy, Anthony Milford Ward, Julietta Patnick, Christopher P. Price, Janet Rimmer, Cathie Sturgeon, Peter White, Naomi E. Allen, Use of Prostate-Specific Antigen (PSA) Isoforms for the Detection of Prostate Cancer in Men with a PSA Level of 2–10 ng/ml: Systematic Review and Meta-Analysis European Urology. ,vol. 48, pp. 386- 399 ,(2005) , 10.1016/J.EURURO.2005.04.015
Julius Gudmundsson, Soren Besenbacher, Patrick Sulem, Daniel F Gudbjartsson, Isleifur Olafsson, Sturla Arinbjarnarson, Bjarni A Agnarsson, Kristrun R Benediktsdottir, Helgi J Isaksson, Jelena P Kostic, Sigurjon A Gudjonsson, Simon N Stacey, Arnaldur Gylfason, Asgeir Sigurdsson, Hilma Holm, Unnur S Bjornsdottir, Gudmundur I Eyjolfsson, Sebastian Navarrete, Fernando Fuertes, Maria D Garcia-Prats, Eduardo Polo, Ionel A Checherita, Mariana Jinga, Paula Badea, Katja K Aben, Jack A Schalken, Inge M Van Oort, Fred C Sweep, Brian T Helfand, Michael Davis, Jenny L Donovan, Freddie C Hamdy, Kristleifur Kristjansson, Jeffrey R Gulcher, Gisli Masson, Augustine Kong, William J Catalona, Jose I Mayordomo, Gudmundur Geirsson, Gudmundur V Einarsson, Rosa B Barkardottir, Eirikur Jonsson, Viorel Jinga, Dana Mates, Lambertus A Kiemeney, David E Neal, Unnur Thorsteinsdottir, Thorunn Rafnar, Kari Stefansson, Genetic correction of PSA values using sequence variants associated with PSA levels. robotics and applications. ,vol. 2, ,(2010) , 10.1126/SCITRANSLMED.3001513
Simon A. Williams, Yi Xu, Angelo M. De Marzo, John T. Isaacs, Samuel R. Denmeade, Prostate-specific antigen (PSA) is activated by KLK2 in prostate cancer ex vivo models and in prostate-targeted PSA/KLK2 double transgenic mice. The Prostate. ,vol. 70, pp. 788- 796 ,(2010) , 10.1002/PROS.21111