Effect of Aging on Vasopressin, Catecholamines, and Alpha2-Adrenergic Receptors
作者： Michael Bursztyn , Margaret Bresnahan , Irene Gavras , Haralambos Gavras
DOI: 10.1111/J.1532-5415.1990.TB01420.X
关键词: Norepinephrine (medication) 、 Population 、 Vasopressin 、 Adrenergic receptor 、 Internal medicine 、 Epinephrine 、 Endocrinology 、 Alpha (ethology) 、 Receptor 、 Medicine 、 Antagonist
摘要: To characterize normal changes with aging, we measured plasma levels of epinephrine, norepinephrine, and vasopressin, as well alpha 2-adrenergic receptor numbers (Bmax) the antagonist dissociation constant (Kd) from platelet-derived membranes white, younger (aged 28 +/- 6 years, n = 30) older 70 4 41) normotensive, healthy volunteers. There were no differences in resting vasopressin or epinephrine at 0.83 360 120 pmol/L versus 1.0 0.2 450 420 subjects, respectively. However, norepinephrine was significantly higher (2.87 1.34 nmol/L) subjects (1.50 0.53 nmol/L, P less than .01). Platelet 2-receptor lower 289 79 fmol/mg protein 388 81 (P .01), compatible but not proof down-regulation by norepinephrine. Kd, representing affinity, similar both groups. Therefore, studies hormone status various pathologic conditions should always take into account attributable to age subject population.
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