Age-dependent decrease of α2-adrenergic receptor number in human platelets
作者： Otto-Erich Brodde , Manfred Anlauf , Nikolaus Graben , Klaus Dietrich Bock
DOI: 10.1016/0014-2999(82)90456-3
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摘要: In 36 healthy subjects of various ages (14–76 years) the number α 2 -adrenergic receptors in platelets — as determined by [ 3 H]yohimbine binding and plasma catecholamine levels were measured. A highly significant negative correlation (r= −0.666, P age was found; on contrary, concentrations increased with increasing age. Thus, reduced responses elderly to adrenergic stimuli may be due receptors.
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