Oxidative Stress-Driven Cardiotoicity of Cancer Drugs

摘要: Despite the recent advances in cancer handling, cytotoxic chemotherapy remains as main approach for treating patients. These drugs are associated with a variety of acute and long-term side effects, including several levels cardiac injury. Cardiotoxicity can be found such patients subclinical disease – where symptoms not evidenced but changes observed blood or clinically symptomatic. The basis chemotherapy-induced cardiotoxicity is multifactorial, most present same mechanism damage: generation free radicals redox homeostasis imbalance. In addition, monoclonal antibodies employed personalized medicine against have shown degrees this contect, chapter discusses capable to generate oxidative stress during treatment, highlight mechanisms mediated by mediators that involved damage.