Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines.

摘要: Recently published in Nature: Cell Death and Discovery, Mahbub et al.1 have demonstrated that polyphenols can synergistically enhance the action of topoisomerase II inhibitors: doxorubicin etoposide leukaemia cells. A reduction glutathione (GSH) was strongly associated with sensitising cells to pro-apoptotic effects when used combination with or etoposide. Importantly, II inhibitors were combined, it possible induce a synergistic decrease cell proliferation (measured as ATP levels), cell-cycle arrest induction apoptosis in leukaemia lines.