Melanoma Cells Selected for Adhesion to Laminin Peptides Have Different Malignant Properties
作者： Hynda K. Kleinman , Maura C. Kibbey , Keizo Yamamura
DOI:
关键词: Cell culture 、 Pathology 、 Metastasis 、 Melanoma 、 In vitro 、 Glycoprotein 、 Molecular biology 、 Biology 、 Laminin 、 In vivo 、 Fibronectin
摘要: Laminin is an important promoter of cell-matrix interactions. A number active laminin domains have been defined by use synthetic peptides. The Tyr-Ile-Gly-Ser-Arg (YIGSR) sequence on the B1 chain in can decrease tumor growth and metastasis, whereas another containing Ser-Ile-Lys-Val-Ala-Val (SIKVAV) increase metastasis. Here, we selected B16-F10 melanoma cells adherence or nonadherence to either YIGSR- SIKVAV-coated dishes established 3 variants: YIGSR-adherent (Y+), YIGSR-nonadherent (Y-), SIKVAV-nonadherent (S-). SIKVAV-adherent were not because most F10 attached dish. These cell lines proliferated at same rate as parent equally laminin, collagen IV, fibronectin. Y+ produced rapidly growing tumors after s.c. injection twice many lung colonies parental i.v. injection. In contrast, Y- more slowly one-third relative S- yielded similar numbers but smaller than data suggest that interactions with YIGSR site are probably for both colony formation a target organ (lung) subsequent growth, while SIKVAV-containing may be growth.
aacrjournals.org参考文章(32)
Isaiah J. Fidler, Douglas M. Gersten, Ian R. Hart, The biology of cancer invasion and metastasis. Advances in Cancer Research. ,vol. 28, pp. 149- 250 ,(1978) , 10.1016/S0065-230X(08)60648-X
M Sasaki, Y Yamada, The laminin B2 chain has a multidomain structure homologous to the B1 chain. Journal of Biological Chemistry. ,vol. 262, pp. 17111- 17117 ,(1987) , 10.1016/S0021-9258(18)45498-1
Hynda K. Kleinman, Benjamin S. Weeks, H. William Schnaper, Maura C. Kibbey, Keizo Yamamura, Derrick S. Grant, The laminins: a family of basement membrane glycoproteins important in cell differentiation and tumor metastases. Vitamins and Hormones Series. ,vol. 47, pp. 161- 186 ,(1993) , 10.1016/S0083-6729(08)60446-X
K Tashiro, G C Sephel, B Weeks, M Sasaki, G R Martin, H K Kleinman, Y Yamada, A synthetic peptide containing the IKVAV sequence from the A chain of laminin mediates cell attachment, migration, and neurite outgrowth. Journal of Biological Chemistry. ,vol. 264, pp. 16174- 16182 ,(1989) , 10.1016/S0021-9258(18)71604-9
R. Timpl, H. Rohde, P.G. Robey, S.I. Rennard, J.M. Foidart, G.R. Martin, Laminin--a glycoprotein from basement membranes. Journal of Biological Chemistry. ,vol. 254, pp. 9933- 9937 ,(1979) , 10.1016/S0021-9258(19)83607-4
Konrad Beck, Irene Hunter, Jürgen Engel, Structure and function of laminin: anatomy of a multidomain glycoprotein The FASEB Journal. ,vol. 4, pp. 148- 160 ,(1990) , 10.1096/FASEBJ.4.2.2404817
H K Kleinman, A Albini, G R Martin, S A Aaronson, Y Iwamoto, R N McEwan, J M Kozlowski, A Rapid in Vitro Assay for Quantitating the Invasive Potential of Tumor Cells Cancer Research. ,vol. 47, pp. 3239- 3245 ,(1987)
Salvador F. Aliño, Fernando J. Unda, Gorka Pérez-Yarza, Laminin surface binding sites and metastatic potential of 3LL tumor cells, increased by indomethacin Biochemical and Biophysical Research Communications. ,vol. 167, pp. 731- 738 ,(1990) , 10.1016/0006-291X(90)92086-F
Jeannette Graf, Yukihide Iwamoto, Makoto Sasaki, George R. Martin, Hynda K. Kleinman, Frank A. Robey, Yoshihiko Yamada, Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding Cell. ,vol. 48, pp. 989- 996 ,(1987) , 10.1016/0092-8674(87)90707-0
George Panayotou, Peter End, Monique Aumailley, Rupert Timpl, Jürgen Engel, Domains of laminin with growth-factor activity Cell. ,vol. 56, pp. 93- 101 ,(1989) , 10.1016/0092-8674(89)90987-2