Single- versus Triple-Drug Chemoembolization for Hepatocellular Carcinoma: Comparing Outcomes by Toxicity, Imaging Response, and Survival.
作者： Samdeep K Mouli , Ryan Hickey , Bartley Thornburg , Kent T Sato , Kush Desai
DOI: 10.1016/J.JVIR.2016.01.135
关键词: Surgery 、 Carcinoma 、 Portal vein thrombosis 、 Proportional hazards model 、 Internal medicine 、 Gastroenterology 、 Hepatocellular carcinoma 、 Medicine 、 Confidence interval 、 Stage (cooking) 、 Retrospective cohort study 、 Liver cancer
摘要: Abstract Purpose To determine the efficacy of single- versus triple-drug chemoembolization for treatment hepatocellular carcinoma, as measured by toxicity, tumor response, time to progression (TTP), and overall survival (OS). Materials Methods A single-center retrospective review was performed on 337 patients who underwent over a 14-year period; 172 conventional transarterial chemoembolization, 165 single-agent doxorubicin chemoembolization. Imaging characteristics clinical follow-up after were evaluated TTP. response determined per World Health Organization European Association Study Liver criteria. OS from first calculated. Results Median TTP similar between groups: 7.9 months (95% confidence interval [CI], 7.1–9.4) 6.8 CI, 4.6–8.6) triple- single-drug regimens, respectively ( P > .05). For median varied significantly Barcelona Clinic Cancer (BCLC) stage: A, 40.8 months; B, 36.4 C, 10.9 Conclusions Single-agent with ethiodized oil demonstrates acceptable OS. compare favorably traditional therapy.
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