Mortality and morbidity of newly diagnosed heart failure treated with statins A propensity-adjusted cohort study

摘要: Abstract Background The effect of treatment with statins on the prognosis newly diagnosed heart failure (ndHF) is not established. We evaluate relationship commencing (CTS) mortality and morbidity ndHF, systolic (HF-DSF) non-systolic (HF-PSF). Methods Prospective propensity-adjusted cohort study over 5 years 2573 patients ndHF. main outcomes were all-cause cardiovascular mortality, hospitalizations visits. analyze independent CTS morbidity, stratifying for co-morbidity, after adjusting potential confounders. Results 1343 (52.2%) CTS, 1071 (39.5%) died, 1729 (67.2%) hospitalized. was associated only a lower mortality: RR HF-overall (CI 95%) 0.23 (0.10 to 0.36), HF-PSF 0.34 (0.21 0.47), HF-DSF 0.20 (0.09 0.31), but dose-dependency (statin>20 mg/day vs. statin P Conclusion commencement dose-dependent reduction ndHF (systolic or non-systolic).