Heart failure with preserved ejection fraction: Refocusing on diastole
作者： Antonio Abbate , Ross Arena , Nayef Abouzaki , Benjamin W. Van Tassell , Justin Canada
DOI: 10.1016/J.IJCARD.2014.11.106
关键词: Internal medicine 、 Normal limit 、 In patient 、 Cardiology 、 Heart failure with preserved ejection fraction 、 Exercise intolerance 、 Diastole 、 Ejection fraction 、 Medicine 、 Heart failure 、 Clinical syndrome
摘要: Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome of exercise intolerance and/or congestion, in the presence left ventricular (LV) within normal limits (i.e. LVEF>50%). Determining impaired LV relaxation filling (diastolic dysfunction) HFpEF needed to pragmatically distinguish it from other cardiac and non-cardiac conditions where symptoms are not due HF. There multiple mechanisms for diastolic dysfunction ranging structural abnormalities functional derangements yet tailored therapies lacking. Treatments proven effective HF systolic have failed show significant benefit patients HFpEF, which prognosis remains poor. This review will discuss challenges inherent use diagnostic criteria differential diagnosis, prognostic evaluation, treatment, highlighting need more research this field.
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