Layer-dependent wall properties of abdominal aortic aneurysms: Experimental study and material characterization.

摘要: Mechanical testing and in-depth characterization of the abdominal aortic aneurysm wall from fifteen patients undergoing open surgery was performed to establish layer-dependent tissue properties that are non-available in literature. Quantitative microscopic evaluation identify spatial organization collagen-fiber network. Among a number candidate models, four-fiber family (microstructure-motivated) model, especially including dispersions fiber angles about main directions, superior Fung- Gasser-type models fitting quality allowed, though it presented practical difficulty parameter estimation, so an analysis conducted aiding identification more specific diagonal- circumferential-fiber model for all three layers. The adventitia stiffer stronger than other layers, owing its increased collagen content, contribution response intact augmented being under greater residual tension media, whereas intima compression. All layers were circumferentially longitudinally, due preferential arrangement along axis. histologically-guided material layered herein is expected assist clinical decision, by developing reliable criteria predict rupture risk aneurysms, optimize endovascular interventions.