The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice.

摘要: Abstract The High Drinking in the Dark mouse lines (HDID-1 and HDID-2) were selectively bred to achieve high blood ethanol concentrations (BECs) (DID) task, a widely used model of binge-like intake 20% ethanol. There are several components that differentiate DID from other animal models intake: time day testing, length access, single-bottle individual housing. Here, we sought determine how some these factors contribute observed HDID mice. HDID-1, HDID-2, non-selected HS/NPT mice tested series experiments where one following was manipulated: fluid choice, number bottles, housing condition. We (1) intoxicating BECs DID, even when they group-housed; (2) continue show elevated relative during an extended access session, but this is most apparent first four hours access; (3) offering water choice prevents HDID-1 mice, not necessarily HDID-2 Together, results suggest lack paradigm, together with important contributing These further differences between response procedural manipulations condition bottle highlighting distinct characteristics each possess, despite being for same phenotype.