Chemokines, chemokine receptors and small-molecule antagonists: recent developments.

作者: James J Onuffer , Richard Horuk

DOI: 10.1016/S0165-6147(02)02064-3

关键词: ReceptorCell biologyG protein-coupled receptorChemokine receptorBiologyChemokineNeuroscienceRhodopsinDrug discoverySmall moleculeStructural biology

摘要: … Chemokine receptors belong to the … to chemokine receptors as therapeutic targets, the status of low molecular weight antagonists in clinical development, molecular modeling of receptor…

参考文章(57)
Jie Yang, Ci-Quan Liu, Molecular modeling on human CCR5 receptors and complex with CD4 antigens and HIV-1 envelope glycoprotein gp120 Acta Pharmacologica Sinica. ,vol. 21, pp. 29- 34 ,(2000)
Krzysztof Palczewski, Juan Ballesteros, G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. Current Opinion in Drug Discovery & Development. ,vol. 4, pp. 561- 574 ,(2001)
Jonathan S. Duke-Cohan, Wen Tang, Stuart F. Schlossman, Attractin: a cub-family protease involved in T cell-monocyte/macrophage interactions. Advances in Experimental Medicine and Biology. ,vol. 477, pp. 173- 185 ,(2002) , 10.1007/0-306-46826-3_20
Lars Ole Gerlach, Renato T. Skerlj, Gary J. Bridger, Thue W. Schwartz, Molecular Interactions of Cyclam and Bicyclam Non-peptide Antagonists with the CXCR4 Chemokine Receptor Journal of Biological Chemistry. ,vol. 276, pp. 14153- 14160 ,(2001) , 10.1074/JBC.M010429200
Jalal Vakili, Ludger Ständker, Michel Detheux, Gilbert Vassart, Wolf-Georg Forssmann, Marc Parmentier, Urokinase Plasminogen Activator and Plasmin Efficiently Convert Hemofiltrate CC Chemokine 1 into Its Active [9–74] Processed Variant The Journal of Immunology. ,vol. 167, pp. 3406- 3413 ,(2001) , 10.4049/JIMMUNOL.167.6.3406
Sara S. Cheng, Joyce J. Lai, Nicholas W. Lukacs, Steven L. Kunkel, Granulocyte-Macrophage Colony Stimulating Factor Up-Regulates CCR1 in Human Neutrophils The Journal of Immunology. ,vol. 166, pp. 1178- 1184 ,(2001) , 10.4049/JIMMUNOL.166.2.1178
B.S. Sachais, R.M. Snider, J.A. Lowe, J.E. Krause, Molecular basis for the species selectivity of the substance P antagonist CP-96,345. Journal of Biological Chemistry. ,vol. 268, pp. 2319- 2323 ,(1993) , 10.1016/S0021-9258(18)53777-7
Sigrid Hatse, Katrien Princen, Lars-Ole Gerlach, Gary Bridger, Geoffrey Henson, Erik De Clercq, Thue W. Schwartz, Dominique Schols, Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. Molecular Pharmacology. ,vol. 60, pp. 164- 173 ,(2001) , 10.1124/MOL.60.1.164
Peter S. Topham, Vilmos Csizmadia, Dulce Soler, Dawn Hines, Craig J. Gerard, David J. Salant, Wayne W. Hancock, Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis Journal of Clinical Investigation. ,vol. 104, pp. 1549- 1557 ,(1999) , 10.1172/JCI7707
Ingrid De Meester, Stephan Korom, Jo Van Damme, Simon Scharpé, CD26, let it cut or cut it down Immunology Today. ,vol. 20, pp. 367- 375 ,(1999) , 10.1016/S0167-5699(99)01486-3