Synthesis and anticancer activity of sclerophytin-inspired hydroisobenzofurans
作者： T. David Bateman , Aarti L. Joshi , Kwangyul Moon , Elena N. Galitovskaya , Meenakshi Upreti
DOI: 10.1016/J.BMCL.2009.10.079
关键词: Bicyclic molecule 、 Chemistry 、 Cytotoxicity 、 Epidermoid carcinoma 、 Chemical synthesis 、 Cell growth 、 In vitro 、 Cell culture 、 Structure–activity relationship 、 Stereochemistry 、 Organic chemistry 、 Clinical biochemistry 、 Molecular medicine 、 Biochemistry 、 Molecular biology 、 Drug discovery 、 Pharmaceutical Science
摘要: Abstract Three structurally related sets of hydroisobenzofuran analogs sclerophytin A were prepared in three or four steps from ( S )-(+)-carvone via an aldol-cycloaldol sequence. The most potent members each set exhibited IC 50 ’s 1–3 μM growth inhibitory assays against KB3 cells. NCI 60-cell line 5-dose assay for analog 6h revealed a GI = 0.148 μM and LC = 9.36 μM the RPMI-8226 leukemia cell line, = 0.552 μM = 26.8 μM HOP-92 non-small lung cancer line.
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