Enantioselective Synthesis of (-)-Sclerophytin A by a Stereoconvergent Epoxide Hydrolysis
作者： Bin Wang , Armando P. Ramirez , Justin J. Slade , James P. Morken
DOI: 10.1021/JA108185Z
关键词: Radical cyclization 、 Organic chemistry 、 Stereochemistry 、 Epoxide 、 Sclerophytin A 、 Stereoselectivity 、 Natural product 、 Chemistry 、 Enantioselective synthesis 、 Hydrolysis
摘要: The cytotoxic natural product (−)-sclerophytin A was constructed in 13 steps from geranial. Highlights the synthesis are a stereoselective Oshima−Utimoto reaction, Shibata−Baba indium-promoted radical cyclization, and novel stereoconvergent epoxide hydrolysis.
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