Process for the preparation of pyridine-2, 3-dicarboxylic acids

摘要: Pyridine-2,3-dicarboxylic acids are prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic in a liquid medium which lacks active decarboxylase and has pH from 4 to 9, an ionic strength below about 1 molar, low concentration metal cations complex anions. In close temporal proximity, the 2-hydroxy-3-carboxy­ muconic acid semialdehyde forms is allowed react with source ammonia or primary amine, avoiding substantial decarboxylation.