Protection of 2′‐Hydroxy Functions of Ribonucleosides
作者： Colin B. Reese
DOI: 10.1002/0471142700.NC0202S00
关键词: Telecommunications 、 Context (language use) 、 Polyribonucleotides 、 Computer science 、 Combinatorial chemistry
摘要: The main purpose of this article is to discuss 2′-protection in the context effective oligoribonucleotide synthesis. Emphasis placed on 2′-protecting groups choice synthesis oligo-and polyribonucleotides, and requirements that a protective group must satisfy become 2′-hydroxyl-protecting choice. Finally, unit discusses issue 2′-O-acyl 2′-O-silyl migration 3′-hydroxy function ribonucleosides during protection, along with consequences conditions used for their removal stability internucleotide linkages.
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