Liver injury-preventive effect of tea theanine in rats

作者: P. He , S. Wada , N. Watanabe , K. Sugiyama

DOI: 10.1111/J.1365-2621.2000.TB15951.X

关键词: TheanineRat liverChemistryActive compoundPharmacologyGlutamic acidLiver injuryGreen teaGalactosamineBiochemistryGlutamine

摘要: : This study was conducted to isolate the constituent, which had a preventive effect on D-galactosamine-induced rat liver injury, from 70% ethanol-soluble fraction of Japanese green tea. Theanine (glutamic acid γ-ethylamide) identified as active compound, and injury-preventive theanine dose-dependent. L-Glutamic γ-ethyl ester, but not glutamine, also brought about significantly injury when added diet at equimolar levels that 1% theanine. The results indicate is one effective constituents tea in preventing injury.

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