Computer-Assisted Modeling, Prediction, and Multifactor Optimization of Hydrophobic Compounds in Liquid Chromatography
作者： Yu Ping Zhang , Wen Jun Gong , Kwang Pill Lee , Seong Ho Choi , Anantha Tyengar Gopalan
DOI: 10.1007/S00604-005-0419-3
关键词: Separation time 、 Mathematical simulation 、 Chemistry 、 Resolution (mass spectrometry) 、 Elution 、 High-performance liquid chromatography 、 Phase (matter) 、 Chromatography 、 Phase composition 、 Volumetric flow rate
摘要: The traditional overlapping resolution mapping (ORM) scheme was modified for application in HPLC with the flow rate of mobile phase as a new factor. composition and were taken parameters to influence effective elution time. Chromatograms obtained separation 16 compounds ten trial conditions. Computer-assisted mathematical simulation used obtain optimum conditions time compounds. validity model developed confirmed by experiments.
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