Optimization of the capillary electrophoretic separation of bisbenzylisoquinoline alkaloids by an overlapping resolution mapping scheme
作者： Shao-Wen Sun , An-Cheng Wu
DOI: 10.1016/S0021-9673(98)00416-6
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摘要: The micellar electrokinetic chromatographic (MEKC) separation of eight bisbenzylisoquinoline (BBI) alkaloids, aromoline, berbamine, colorflammine, homoaromoline, isotetrandrine, obamegine, tetrandrine and thalrugosine, was optimized by using the overlapping resolution mapping (ORM) scheme. Three critical parameters electrophoretic media, i.e. surfactant (sodium cholate), organic modifier (acetonitrile) pH, were chosen for optimization, with their working ranges being appropriately defined. Seven experiments conducted to obtain overlapped diagram from which area maximum separations could be located. Using conditions a point in this area, BBI compounds baseline separated within 20 min. elution order found related lipophilicity. resolution, run time, efficiency limits detection MEKC method compared those high-performance liquid chromatography developed previously.
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sci-hub.se 参考文章(14)
K.D. Altria, J.S. Howells, Quantitative determination of organic solvents by capillary electrophoresis using indirect UV detection Journal of Chromatography A. ,vol. 696, pp. 341- 348 ,(1995) , 10.1016/0021-9673(95)00036-M
M. M. Rogan, K. D. Altria, D. M. Goodall, Plackett-Burman experimental design in chiral analysis using capillary electrophoresis Chromatographia. ,vol. 38, pp. 723- 729 ,(1994) , 10.1007/BF02269627
Jon W. Banning, Kadhim N. Salman, Popat N. Patil, A pharmacological study of two bisbenzylisoquinoline alkaloids, thalistyline and obamegine. Journal of Natural Products. ,vol. 45, pp. 168- 177 ,(1982) , 10.1021/NP50020A010
Mark E.P. Hows, David Perrett, Jack Kay, Optimisation of a simultaneous separation of sulphonamides, dihydrofolate reductase inhibitors and β-lactam antibiotics by capillary electrophoresis Journal of Chromatography A. ,vol. 768, pp. 97- 104 ,(1997) , 10.1016/S0021-9673(97)00107-6
C. L. Ng, C. P. Ong, H. K. Lee, S. F. Y. Li, Systematic optimization of micellar electrokinetic chromatographic separation of flavonoids Chromatographia. ,vol. 34, pp. 166- 172 ,(1992) , 10.1007/BF02276132
Shao-Wen Sun, Li-Yun Chen, Optimization of capillary electrophoretic separation of quinolone antibacterials using the overlapping resolution mapping scheme Journal of Chromatography A. ,vol. 766, pp. 215- 224 ,(1997) , 10.1016/S0021-9673(96)00992-2
Johan. Vindevogel, Pat. Sandra, Resolution optimization in micellar electrokinetic chromatography: use of Plackett-Burman statistical design for the analysis of testosterone esters Analytical Chemistry. ,vol. 63, pp. 1530- 1536 ,(1991) , 10.1021/AC00015A007
Sock Khim. Yeo, Chye Peng. Ong, Sam Fong Yau. Li, Optimization of high-performance capillary electrophoresis of plant growth regulators using the overlapping resolution mapping scheme Analytical Chemistry. ,vol. 63, pp. 2222- 2225 ,(1991) , 10.1021/AC00020A006
Juho H. Jumppanen, Susanne K. Wiedmer, Heli Sirén, Marja-Liisa Riekkola, Heikki Haario, Optimized separation of seven corticosteroids by micellar electrokinetic chromatography. Electrophoresis. ,vol. 15, pp. 1267- 1272 ,(1994) , 10.1002/ELPS.11501501191
Jun Wu, Ming Keong Wong, Sam Fong Yau Li, Hian Kee Lee, Choon Nam Ong, Combination of orthogonal array design and overlapping resolution mapping for optimizing the separation of heterocyclic amines by capillary zone electrophoresis Journal of Chromatography A. ,vol. 709, pp. 351- 359 ,(1995) , 10.1016/0021-9673(95)00459-Z