Osteosarcoma in young children
作者： Harry Kozakewich , Antonio R. Perez-Atayde , Gordon F. Vawter , Allen M. Goorin , Robert H. Wilkinson
DOI: 10.1002/1097-0142(19910201)67:3<638::AID-CNCR2820670319>3.0.CO;2-T
关键词: Cancer 、 Chemotherapy 、 Pediatrics 、 Osteosarcoma 、 Methotrexate 、 Surgical resection 、 Aggressive chemotherapy 、 Surgery 、 Medicine 、 Amputation 、 Cancer research 、 Oncology
摘要: The clinicopathologic features of osteosarcoma in 12 children younger than 16 years age treated at Children's Hospital and Dana-Farber Cancer Institute, Boston, during a 70-year time period are presented. Only one six before 1972 is long-term survivor. Four (67%) after disease-free with an average follow-up 8.8 years. year marked the onset use effective chemotherapy osteosarcoma, namely, high-dose methotrexate leucovorin rescue. It would appear that pathologic behavior young similar to older adolescents. A combination complete (wide) surgical resection or amputation aggressive offers best chance survival.
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