CHAPTER 280 – Cross-Talk between Nuclear Receptors and Other Transcription Factors
作者： Peter Herrlich
DOI: 10.1016/B978-012124546-7/50642-2
关键词: Hormone 、 Neuroscience 、 Transcription (biology) 、 Immunology 、 Transcription factor 、 Immune system 、 Transcription preinitiation complex 、 Vitamin D and neurology 、 Retinoic acid 、 Nuclear receptor 、 Biology
摘要: This chapter deals with a particular organismic control mechanism established by hormones. Glucocorticoid hormones or retinoic acid as well vitamin D counteract proliferative, inflanmiatory, and immune responses. is why glucocorticoids are widely used in treating unwanted inflammatory reactions, asthma, autoimmune diseases, leukemia. The cross-talk function of nuclear receptors essential for adult life. It exerted interference the activity another transcription factor at step after formation preinitiation complex. mutual offers way to adjust pro- antiproliferative an elegant fine-tuned way. A new class cofactors appears be involved cross-talk. Because long-term systemic therapy can result severe side effects such osteoporosis joint necroses, current efforts directed toward distinguishing whether caused GRE-dependent genetic programs they intimately connected GR, which unavoidably these therapies. may possible select ligands that activate only function.
sci-hub.st 参考文章(69)
J.M. Gauthier, B. Bourachot, V. Doucas, M. Yaniv, F. Moreau-Gachelin, Functional interference between the Spi-1/PU.1 oncoprotein and steroid hormone or vitamin receptors. The EMBO Journal. ,vol. 12, pp. 5089- 5096 ,(1993) , 10.1002/J.1460-2075.1993.TB06203.X
P. Herrlich, M. Göttlicher, The anti-inflammatory action of glucocorticoid hormones. Ernst Schering Research Foundation workshop. pp. 297- 304 ,(2002) , 10.1007/978-3-662-04660-9_16
H. König, H. Ponta, H.J. Rahmsdorf, P. Herrlich, Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. The EMBO Journal. ,vol. 11, pp. 2241- 2246 ,(1992) , 10.1002/J.1460-2075.1992.TB05283.X
L. Shemshedini, R. Knauthe, P. Sassone-Corsi, A. Pornon, H. Gronemeyer, Cell‐specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors. The EMBO Journal. ,vol. 10, pp. 3839- 3849 ,(1991) , 10.1002/J.1460-2075.1991.TB04953.X
V. Doucas, G. Spyrou, M. Yaniv, Unregulated expression of c-Jun or c-Fos proteins but not Jun D inhibits oestrogen receptor activity in human breast cancer derived cells. The EMBO Journal. ,vol. 10, pp. 2237- 2245 ,(1991) , 10.1002/J.1460-2075.1991.TB07760.X
J. Drouin, Y.L. Sun, M. Chamberland, Y. Gauthier, A. De Léan, M. Nemer, T.J. Schmidt, Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. The EMBO Journal. ,vol. 12, pp. 145- 156 ,(1993) , 10.1002/J.1460-2075.1993.TB05640.X
N. Auphan, J. A. DiDonato, C. Rosette, A. Helmberg, M. Karin, Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis Science. ,vol. 270, pp. 286- 290 ,(1995) , 10.1126/SCIENCE.270.5234.286
M. Cavigelli, F. Dolfi, F. X. Claret, M. Karin, Induction of c‐fos expression through JNK‐mediated TCF/Elk‐1 phosphorylation. The EMBO Journal. ,vol. 14, pp. 5957- 5964 ,(1995) , 10.1002/J.1460-2075.1995.TB00284.X
S. Heck, M. Kullmann, A. Gast, H. Ponta, H.J. Rahmsdorf, P. Herrlich, A.C. Cato, A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP‐1. The EMBO Journal. ,vol. 13, pp. 4087- 4095 ,(1994) , 10.1002/J.1460-2075.1994.TB06726.X
Lisa G. Rider, Michael A. Beaven, Noriyasu Hirasawa, Francesca Santini, Francesca Santini, Activation of the mitogen-activated protein kinase cascade is suppressed by low concentrations of dexamethasone in mast cells. Journal of Immunology. ,vol. 157, pp. 2374- 2380 ,(1996)