A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP‐1.

摘要: Steroid receptors activate and repress genes. An important class of genes that they is controlled by the transcription factor AP-1. The activity AP-1 inhibited receptor, a mechanism exploited for therapy various forms pathological hyperproliferation in humans. We show here point mutations DNA binding domain choice steroid ligands repression transactivation functions glucocorticoid receptor (GR) are separable entities. While activation glucocorticoid-regulated promoters require GR dimerization, we present data suggest function monomers.