Association Between Polymorphisms of DNA Repair Gene XRCC1 and DNA Damage in Asbestos-Exposed Workers

摘要: OBJECTIVE To compare the asbestos-induced DNA damage and repair capacities of between 104 asbestos-exposed workers 101 control in Qingdao City China to investigate possible association polymorphisms codon 399 XRCC1 susceptibility asbestosis. METHODS levels peripheral blood lymphocytes were determined by comet assay, genetic samples from 51 asbestosis cases 53 non-asbestosis with a similar asbestos exposure history analyzed PCR/RFLP. RESULTS The basal scores (3.95 +/- 2.95) significantly higher than (0.10 0.28). After 1 h H2O2 stimulation, exhibited different increases. 4 period, 50.98 19.53 18.32 12.04 controls. residual (RD) was greater (P<0.01) (35.62%) controls (27.75%). polymorphism not associated increased risk But compared gene (polymorphisms 399) induced asbestos, Gln/Gln, Gln/Arg, Arg/Arg 40.26 18.94, 38.03 28.22, 32.01 11.65, respectively, which those same genotypes (25.58 11.08, 37.08 14.74, 29.38 10.15). There significant differences Gln/Gln Student's t-test (P<0.05 or 0.01). exposed but without statistically difference. CONCLUSIONS Exposure may be related capacity cells H2O2-induced damage. responsible for inter-individual capacities.